Biosphere® Particles

---

Optimal Sphere Particle Packing

• 3-dimensional packing of spheres results in 100% interconnected porosity (no small pores or blocked off channels)

• Optimal packing allows for bone growth throughout entire implant area

Irregular Particle packing

• Irregular particles with small particles, sharp edges, and flat surfaces can pack into dense configurations

• Dense packing can reduce bone in-growth due to small pore sizes and blocked off porosity.  This can limit bone growth to the periphery of the implant area.

---

Bimodal Size Range

• Due to the spherical shape, BioSphere® particles can be precisely separated into narrow size ranges. 

• A bimodal particle distribution can be created by combining specific size ranges.


• The use of specific size ranges allows for control over the dissolution and ion release profile of bioactive glass.


• Small particles resorb faster and generate ions more quickly than larger particles.  Larger particles resorb slower and function as a longer-term scaffold for bone formation.

In-vivo optimization study showed that a 10:90 mixture of small
(90-180 um) spheres and large (355-500 um) spheres provided
the best bone healing

---

Particle Settling

• The spherical particles in BioSphere® Putty take up nearly the entire volume of the Putty while still maintaining an optimal porosity for bone in-growth.


• This enables the bioactive glass particles to remain in contact with the edges of a bone defect after the carrier has been resorbed.


• Other putties with lower particle content and irregular particles can settle following carrier resorption resulting in gaps between the implant material and the surrounding bone.

By minimizing particle settling, BioSphere® Putty remains in
contact with the surrounding bone thereby improving the
bone healing response.